The synthetic efforts to dysibetaine CPb, isolated from Micronesian marine sponge, amenable to analog synthesis are reported. Cyclopropane was constructed by a sulfonium ylide-mediated reaction and enantioselective desymmetrization was performed by methanolysis mediated by a quinine derivative. (+)-N-(Desmethyl)dysibetaine CPb was finally synthesized in 0.37% yield in total 14 steps. This is the first synthesis of the dysibetaine CPb analog.