Multi-variable prioritized control study is carried out using model predictive control (MPC) algorithms. The conventional MPC algorithm implements multi-variable control through one augmented objective function and requires weights adjustment for required performance. In order to implement explicit prioritization in multiple control objectives, we have used lexicographic MPC. To achieve better tracking performance, we have used a new MPC algorithm, by modifying the lexicographic constraint, referred to as MLMPC, where tuning of weights is not required. The effectiveness of MLMPC algorithm is demonstrated on a PMMA reactor for controlling the number average molecular weight and the reactor temperature. We have also verified the benefits of proposed algorithm on an experimental single board heater system (SBHS) for controlling temperature of a thin metal plate. These simulation and experimental studies demonstrate the superiority of the proposed method over conventional MPC and lexicographic MPC. Finally, we have presented generalized mathematical solutions to the optimization problem in MLMPC. (C) 2016 Elsevier Ltd. All rights reserved.