Mid-ocean ridge magmatism is driven by seafloor spreading and decompression melting of the upper mantle. Melt production is apparently modulated by glacial-interglacial changes in sea level, raising the possibility that magmatic flux acts as a negative feedback on ice-sheet size. The timing of melt variability is poorly constrained, however, precluding a clear link between ridge magmatism and Pleistocene climate transitions. Here we present well-dated sedimentary records from the East Pacific Rise that show evidence of enhanced hydrothermal activity during the last two glacial terminations. We suggest that glacial maxima and lowering of sea level caused anomalous melting in the upper mantle and that the subsequent magmatic anomalies promoted deglaciation through the release of mantle heat and carbon at mid-ocean ridges.