Lipid polymer hybrid nanospheres encapsulating antiproliferative agents for stent applications

Rajendran JC Bose; Soo-Hong Lee; Hansoo Park

Journal of Industrial and Engineering Chemistry, Vol.36, 284-292, April, 2016

DOI10.1016/j.jiec.2016.02.015 Export Citation

Lipid polymer hybrid nanospheres encapsulating antiproliferative agents for stent applications

Rajendran JC Bose^{1, 2}, Soo-Hong Lee², and Hansoo Park^{1, 3, †}

¹School of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea
²Department of Biomedical Science, College of Life Science, CHA University Republic of Korea, Republic of Korea
³, Korea

E-mail:

Antiproliferative drug (sirolimus or propolis) loaded lipid polymer hybrid nanospheres (LPHNSs) were prepared by single step method. The effects of different lipids on properties of nanocarrier were investigated. Furthermore, anti proliferative efficiency and cytotoxicity of LPHHNSs-propolis or sirolimus were investigated on human aortic smooth muscle cells (HASMCs), and human aortic endothelial primary cells (HAECs) respectively. The characterization of LPHNSs revealed that the lipids used in the formulation influence physiochemical parameters. In vitro studies showed that the encapsulated sirolimus and propolis significantly reduced the proliferation of HASMCs, while maintaining high HAECs viability.

Keywords:Lipid polymer hybrid nanospheres;Antiproliferative drugs;Human aortic smooth muscle cells;Anti proliferation assessment;Cytotoxicity on human aortic endothelial cells

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[Referenced By]

[1] Puranik AS, Dawson ER, Peppas NA, Int. J. Pharm., 441, 665 (2013)

[2] Stefanini GG, Holmes DR, N. Engl. J. Med., 368, 254 (2013)

[3] Heidari M, Mandato CA, Lehoux S, Artery Res., 9, 14 (2015)

[4] Chan JM, Rhee JW, Drum CL, Bronson RT, Golomb G, Langer R, Farokhzad OC, Proc. Natl. Acad. Sci. U. S. A., 108, 19347 (2011)

[5] Khan W, Farah S, Domb AJ, J. Control. Release, 161, 703 (2012)

[6] Hofma S, Smits P, Brouwer J, Velders M, van’t Hof A, Quere M, de Vries C, van Boven A, EuroIntervention: J. EuroPCR Collab. Working Group Interv. Cardiol. Eur. Soc. Cardiol., 10, 1280 (2015)

[7] Roos TU, Heiss EH, Schwaiberger AV, Schachner D, Sroka IM, Oberan T, Vollmar AM, Dirsch VM, J. Nat. Prod., 74, 352 (2011)

[8] Luderer F, Lobler M, Rohm HW, Gocke C, Kunna K, Kock K, Kroemer HK, Weitschies W, Schmitz KP, Sternberg K, J. Biomater. Appl., 25, 851 (2011)

[9] de Souza Ferreira SB, de Assis Dias BR, Obregon CS, Gomes CC, de Araujo Pereira RR, Godoy JSR, Svidzinski TIE, Bruschi ML, Pharm. Dev. Technol., 19, 173 (2014)

[10] Shi X, Chen G, Guo LW, Si Y, Zhu M, Pilla S, Liu B, Gong S, Kent KC, PLOS ONE, 9 (2010)

[11] Krishnakumar KDD, Bose RJC, Jaganathan KS, J. Gastroenterol. Hepatol., 27, 155 (2012)

[12] Krishnakumar D, Kalaiyarasi D, Bose J, Jaganathan K, J. Pharm. Investig., 42, 315 (2012)

[13] Bose RJ, Ahn JC, Yoshie A, Park S, Park H, Lee SH, J. Control. Release, 213, e92 (2015)

[14] Su X, Fricke J, Kavanagh DG, Irvine DJ, Mol. Pharm., 8, 774 (2011)

[15] Park SHLH, Bose RJC, Int. J. Nanomed., 2015(10), 5367 (2015)

[16] Mandal B, Bhattacharjee H, Mittal N, Sah H, Balabathula P, Thoma LA, Wood GC, Nanomed.: Nanotechnol. Biol. Med., 9, 474 (2013)

[17] Zhang L, Chan JM, Gu FX, Rhee JW, Wang AZ, Radovic-Moreno AF, Alexis F, Langer R, Farokhzad OC, ACS Nano, 2, 1696 (2008)

[18] Hu CMJ, Zhang L, Aryal S, Cheung C, Fang RH, Zhang L, Proc. Natl. Acad. Sci. U. S. A., 108, 10980 (2011)

[19] Zou W, Cao G, Xi Y, Zhang N, Drug Deliv., 16, 15 (2009)

[20] Zou J, Zhang X, Yang H, Zhu Y, Ma H, Wang S, J. Cardiothorac. Surg., 6, 69 (2011)

[21] Suo G, Sadarangani A, Tang W, Cowan BD, Wang JY, Reprod. Sci., 21, 1161 (2014)

[22] Kumar R, Kulkarni A, Nabulsi J, Nagesha DK, Cormack R, Makrigiorgos MG, Sridhar S, Drug Deliv. Transl. Res., 3, 299 (2013)

[23] Ichimura T, Jin T, Fujita H, Higuchi H, Watanabe TM, Front. Physiol., 5 (2010)

[24] Galbraith CG, Galbraith JA, J. Cell. Sci., 124, 1607 (2011)

[25] Romero G, Sanz DJ, Qiu Y, Yu D, Mao Z, Gao C, Moya SE, J. Mater. Chem. B, 1, 2252 (2013)

[26] Matter CM, Rozenberg I, Jaschko A, Greutert H, Kurz DJ, Wnendt S, Kuttler B, Joch H, Grunenfelder J, Zund G, J. Cardiovasc. Pharmacol., 48, 286 (2006)

[27] van der Giessen WJ, Sorop O, Serruys PW, Peters-Krabbendam I, van Beusekom HM, JACC: Cardiovasc. Interv., 2, 284 (2009)