화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.36, 326-333, April, 2016
DOI10.1016/j.jiec.2016.02.023  Export Citation
Nano-film coatings onto collagen hydrogels with desired drug release
Daheui Choi, Jiwoong Heo, Joo Hee Park1, Yeonho Jo2, Hyejoong Jeong, Minwook Chang1, Jonghoon Choi2, and Jinkee Hong†
  • School of Chemical Engineering & Material Science, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea
  • 1Department of Ophthalmology, Dongguk University Ilsan Hospital, 27 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, Republic of Korea
  • 2School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea
E-mail:
Hydrogels have been mainly used for biomedical applications owing to their biocompatibility and high water content. However, they have serious limitations such as poor mechanical stability and fast release of the incorporated drug. To overcome these problems, we prepared collagen hydrogel (Col-H) with layer-by-layer (LbL) self-assembled films (Col-H) to develop multifunctional hydrogel. We prepared LbL films using tannic acid and lignin for multi-functional properties. In addition, we incorporated doxorubicin as a model drug, which is widely used for cancer therapy. Furthermore, the prepared films exhibit antibacterial effect against gram-positive and negative bacteria and endure higher compression stress than bare Col-H.
Keywords:Layer-by-layer assembly;Collagen hydrogel;Multifunctional film;Controlled drug release
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