A novel mussel-inspired 3D printed-scaffolds immobilized with bone forming peptide-1 for bone tissue engineering applications: Preparation, characterization and evaluation of its properties

Sang Jin Lee; Ha Hyeon Jo; Seong Keun Kwon; Jin Ho Lee; Wan Doo Kim; Jun Hee Lee; Su A. Park; Il Keun Kwon

Macromolecular Research, Vol.24, No.4, 305-308, April, 2016

DOI10.1007/s13233-016-4049-x Export Citation

A novel mussel-inspired 3D printed-scaffolds immobilized with bone forming peptide-1 for bone tissue engineering applications: Preparation, characterization and evaluation of its properties

Sang Jin Lee^{1, 2}, Ha Hyeon Jo^{1, 3}, Seong Keun Kwon⁴, Jin Ho Lee⁵, Wan Doo Kim^{1, 3}, Jun Hee Lee^{1, 3}, Su A. Park^{1, 3, †}, and Il Keun Kwon^{2, †}

¹Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials, 156 Gajeongbuk-ro, Yuseong-gu, Daejeon, 34103, Korea
²Department of Dental Materials, School of Dentistry, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Korea
³, Korea
⁴Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea
⁵Department of Advanced Materials, Hannam University, 1646 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Korea

E-mail:,

To date, the 3D printing of porous biodegraydable scaffolds has received considerable attention throughout the biomedical field for its suitability to tissue engineering. IIowever, effective surface modification of scaffolds is a current challenge in 3D bio-printing field. In this study, thus we report the 3D printing of a PCL scaffold ciated with DOPA BFPI was then immobilized on the coated scafflolds. As a result, the DPA was well coated and the BFP1 showed higher degrees of cell proferation than uncoated scaffolds. In conclusion, the developed scaffolds may be suitable as bone tissue engineering substrates for use in bone regeneration field.

[References]

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Lee YJ, Lee JH, Cho HJ, Kim HK, Yoon TR, Shin HS, Biomaterials, 34, 5059 (2013)
Kim HK, Kim JH, Park DS, Park KS, Kang SS, Lee JS, Jeong MH, Yoon TR, Biomaterials, 33, 7057 (2012)
Lee SJ, Heo DN, Park JS, Kwon SK, Lee JH, Lee JH, Kim WD, Kwon IK, Park SA, Phys. Chem. Chem. Phys., 17, 2996 (2015)
Lee SJ, Lee DH, Yoon TR, Kim HK, Jo HH, Park JS, Lee JH, Kim WD, Kwon IK, Park SA, Acta Biomater., DOI:10.1016/j.actbio.2016.02.006 (2016)
Ko E, Yang K, Shin J, Cho SW, Biomacromolecules, 14, 3202 (2013)
Cho HJ, Perikamana SKM, Lee JH, Lee JK, Lee KM, Shin CS, Shin HS, ACS Appl. Mater. Interfaces, 6, 11225 (2014)
Yang KS, Lee JS, Kim J, Lee YB, Shin HS, Um SH, Kim JB, Park KI, Lee HS, Cho SW, Biomaterials, 33, 6952 (2012)
Luo Z, Deng Y, Zhang R, Wang M, Bai Y, Zhao Q, Lyu Y, Wei J, Wei S, Colloids Surf. B: Biointerfaces, 131, 73 (2015)
Yin WN, Cao FY, Han K, Zeng X, Zhuo RX, Zhang XZ, J. Mater. Chem. B, 2, 8434 (2014)

[Referenced By]

[1] Murphy SV, Atala A, Nat. Biotechnol., 32, 773 (2014)

[2] Do AV, Khorsand B, Geary SM, Salem AK, Adv. Healthc. Mater., 4, 1742 (2015)

[3] Chen M, Le DQS, Baatrup D, Nygaard JV, Hein S, Bjerre L, Kassem M, Zou X, Bunger C, Acta Biomater., 7, 2244 (2011)

[4] Hutmacher DW, Schantz T, Zein I, Ng KW, Teoh SH, Tan KC, J. Biomed. Mater. Res., 55, 203 (2001)

[5] Cai Y, Li J, Poh CK, Tan HC, Thian ES, Fuh JYH, Sun J, Tay BY, Wang W, J. Mater. Chem. B, 1, 5971 (2013)

[6] Liu YL, Ai KL, Lu LH, Chem. Rev., 114(9), 5057 (2014)

[7] Wang EA, Rosen V, D’alessandro JS, Bauduy M, Cordes P, Harada T, Israel DI, Hewick RM, Kerns KM, Lapan P, Luxenberg DP, Mcquaid D, Moutsatos IK, Nove J, Wozney JM, Proc. Natl. Acad. Sci., 87, 2220 (1990)

[8] Lee YJ, Lee JH, Cho HJ, Kim HK, Yoon TR, Shin HS, Biomaterials, 34, 5059 (2013)

[9] Kim HK, Kim JH, Park DS, Park KS, Kang SS, Lee JS, Jeong MH, Yoon TR, Biomaterials, 33, 7057 (2012)

[10] Lee SJ, Heo DN, Park JS, Kwon SK, Lee JH, Lee JH, Kim WD, Kwon IK, Park SA, Phys. Chem. Chem. Phys., 17, 2996 (2015)

[11] Lee SJ, Lee DH, Yoon TR, Kim HK, Jo HH, Park JS, Lee JH, Kim WD, Kwon IK, Park SA, Acta Biomater., DOI:10.1016/j.actbio.2016.02.006 (2016)

[12] Ko E, Yang K, Shin J, Cho SW, Biomacromolecules, 14, 3202 (2013)

[13] Cho HJ, Perikamana SKM, Lee JH, Lee JK, Lee KM, Shin CS, Shin HS, ACS Appl. Mater. Interfaces, 6, 11225 (2014)

[14] Yang KS, Lee JS, Kim J, Lee YB, Shin HS, Um SH, Kim JB, Park KI, Lee HS, Cho SW, Biomaterials, 33, 6952 (2012)

[15] Luo Z, Deng Y, Zhang R, Wang M, Bai Y, Zhao Q, Lyu Y, Wei J, Wei S, Colloids Surf. B: Biointerfaces, 131, 73 (2015)

[16] Yin WN, Cao FY, Han K, Zeng X, Zhuo RX, Zhang XZ, J. Mater. Chem. B, 2, 8434 (2014)