This work compares the electroactivity of a conventional carbon-paste electrodes and screen-printed carbon electrodes. Potentiometric sensors responsive to sildenafil citrate (SILC) drug (the active component of Viagra) are described, characterized, compared and used for drug assessment. The proposed carbon paste electrode is fully characterized in terms of plasticizer type, response time, life span, soaking time, titrant, pH and temperature. The electrodes exhibited linear response with a Nernstian slope of 58.20 +/- 1 and 58.82 +/- 0.5 mV decade(-1) for SILC in the concentration range from 1.0 x 10(-7) to 1.0 x 10(-2) and 5.30 x 10(-7) to 1.0 x 10(-2) mol L(-1) with good reproducibility for CPE and SPE, respectively. Both CPE and SPE could be used in the pH range 3.0-5.0 and the isothermal coefficient is found to be 0.98 and 0.85 mV/degrees C, respectively. The limit of detection was found to be 9.0 x 10(-8) and 3.5 x 10(-7) mol L(-1) for CPE and SPE, respectively. They were applied to potentiometric determination of SILC in pure state and pharmaceutical preparation under batch conditions. The CPE and SPE sensors display good selectivity for SILC drug over large number of inorganic cations, sugars and amino acids commonly used in drug formulations. The CPE and SPE show high selectivity for the drug under investigation. The results obtained using the fabricated CPE is compared with those obtained by SPE for spiked pharmaceutical samples. (C) 2011 Elsevier B.V. All rights reserved.