Multifunctional magnetic nanocomposites, iron (II) phthalocyanine@Fe3O4/reduced graphene oxide (FePc@Fe3O4/rGO), have been fabricated by a facile equilibrium adsorption process with Fe3O4/rGO nanocomposites as adsorbents. Based on their multifunctionality including magnetic and biomimetic catalytic properties, the as-prepared nanocomposites were further immobilized on the magnetic electrode surface by a fast and simple magnetism-assisted assembly for the reduction of tert-butyl hydroperoxide (TBHP). The proposed biomimetic sensor can be applied to the quantification of TBHP with a linear range over the concentration range of 20 mu M-60 mM and a detection limit of 7.5 mu M (S/N = 3), which offers several advantages including easy preparation, good sensitivity, long-term stability, and low cost. (C) 2013 Elsevier B.V. All rights reserved.