A molecularly imprinted polymer (MIP) based electrochemical sensor for the determination of the anthelmintic drug oxfendazole (OFZ) was developed. The polypyrrole (PPy) was electrochemically synthesized onto a screen printed carbon electrode (SPCE) surface. The determination of OFZ was accomplished on MIP-SPCE using differential pulse (DP) and square wave (SW) voltammetry in phosphate buffer solution pH 3.8. The MIP exhibited a good selectivity for OFZ with respect to the other benzimidazoles veterinary drugs. The applicability of the method was tested with milk samples, spiked with OFZ at 30.0-250.0 mu g kg(-1) with detection limits of 10.0 and 8.0 mu g/kg and the mean recoveries obtained were 101.8 +/- 3.8% and 100.8 +/- 4.2%, at spiking concentration of 50.0 mu g/kg for DPV and SWV, respectively. (C) 2014 Published by Elsevier B.V.