One-step facile ultrasonic method was developed to fabricate graphene/SnO2 (GS) nanocomposite in acidic solution. Graphite oxides were reduced by SnCl2 to graphene sheets in the presence of HCl. The reducing process was accompanied by generation of SnO2 nanoparticles. This work report the detailed study on the GS nanocomposite modified glass carbon electrode. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) measurements were used for the detection of dopamine (DA), ascorbic acid (AA), and uric acid (UA). In AA, DA, and UA ternary mixture, three well-defined peaks located at about 180 mV, 420 mV and 600 mV vs. SCE were obtained. Comparing with either pristine SnO2 or graphene, the prepared graphene/SnO2 nanocomposite shows superior electrocatalytic activity. (C) 2015 Elsevier B.V. All rights reserved.