In this research, the electrochemical properties of a carbon paste electrode modified by synthesized carbon nano particles (CNPs), reduced graphene oxide (RGO), and a novel derivative of hydroquinone, (Z)-4-(naphthalen-1-ylimino methyl) benzene -1, 2-diol, (NYB) were studied by cyclic voltammetry. The modified electrode was used as an electrochemical sensor for catalytic oxidation of isoproterenol (IP), and it exhibited an excellent electrocatalytic activity for IP with a good electrochemical performance, low overpotential and high conductivity. It was found that under optimum conditions (pH = 7.0) in cyclic voltammetry, the oxidation potential of IP would decrease to about 324 mV at the modified electrode as compared to an unmodified carbon paste electrode. Differential pulse voltammetry (DPV) exhibited two linear dynamic ranges of 0.5 to 80.0 mu M and 80.0 to 1000.0 mu M for IP. Also, the selectivity of the prepared electrochemical sensor was checked for determination of IP in the presence of uric add (UA) and Tryptophan (Try). The detection limit for IP was found to be 0.065 mu M. (C) 2015 Elsevier B.V. All rights reserved.