Clathrate hydrate dissociation conditions were measured for four "alternative'' refrigerants, viz. R404A, R406A, R408A and R427A. The experimental measurements were performed within the pressure range of (0.079 to 9.995) MPa and temperatures ranging from (272.7 to 288.7) K. An isochoric pressure-search method was used to perform the measurements. A thermodynamic model based on the van der Waals-Platteeuw (vdW-P) model was applied for the prediction of the dissociation conditions which were compared to the experimental measurements. The fluid phase was modeled using the MHV2 G(E)-EoS mixing rule along with the UNIFAC (original) activity model. The van der Waals-Platteeuw (vdW-P) model was used for the modeling of the hydrate phase. There was reasonable agreement between the experimental and predicted values. (C) 2015 Elsevier Ltd. All rights reserved.