In order to develop a novel controlled-release system of medicine (CRS), chitosan membrane (CM) and bisoleylsulfosuccinic acid (DOLSA)-chitosan hybrid membrane (HM) were synthesized. The permeation behavior of two cisplatin analogs, i.e. cis-diamino dichloro platinum(TI) (CDDP) and cis-diamino tetrachloro platinum(IV) (CDTP), through these membranes were measured, to elucidate the effects of conditions of casting solution for CM preparation and temperature on the permeabilities of cisplatins through these membranes, together with the measurements of their physical and thermodynamic properties. The permeabilities of cisplatins through CM linearly increased with increasing temperature as well as content ratio of acetic acid to water in casting solution. Furthermore, the permeabilities of cisplatins through HM discontinuously changed beyond critical temperature of gel-to-liquid crystal phase transition of DOLSA in HM. This investigation is very useful for developing a novel type of controlled-release membrane available to thermo-chemotherapy.