The aerodynamic performance of wind turbines is significantly influenced by the unsteady flow around the rotor blades. The research on unsteady aerodynamics for Horizontal Axis Wind Turbines (HAWTs) is still poorly understood because of the complex flow physics. In this study, the unsteady aerodynamic configuration of a full-scale HAWT is simulated with consideration of wind shear, tower shadow and yaw motion. The calculated wind turbine which contains tapered tower, rotor overhang and tilted rotor shaft is constructed by making reference of successfully commercial operated wind turbine designed by NEG Micon and Vestas. A validated CFD method is utilized to analyze unsteady aerodynamic characteristics which affect the performance on such a full-scale HAWT. The approach of sliding mesh is used to carefully deal with the interface between static and moving parts in the flow field. The annual average wind velocity and wind profile in the atmospheric border are applied as boundary conditions. Considering the effects of wind shear and tower shadow, the simulation results show that the each blade reaches its maximum and minimum aerodynamic loads almost at the same time during the rotation circle. The blade-tower interaction imposes great impact on the power output performance. The wind turbine produces yaw moment during the whole revolution and the maximum aerodynamic loads appear at the upwind azimuth in the yaw computation case. (C) 2016 Elsevier Ltd. All rights reserved.