Catalytic combustion of methyl isobutyl ketone (MIBK) in diluted air mixtures over a commercial Pt/Al2O3 catalyst was experimentally investigated in a continuous laboratory setup. The experimental data were used to develop a kinetic model of the MIBK combustion over the Pt/Al2O3 catalyst. Among the available kinetic theories, the Langmuir-Hinshelwood one proved to be the most appropriate for the obtained data. The kinetic parameters of the formulated rate expression were estimated using both differential and integral methods. The adequacy of the proposed kinetic model and the estimated parameter values were tested by statistical criteria and thermodynamic consistency. The computation results indicate that the integral method, based on a heterogeneous reactor model, is the recommended approach in the estimation of the kinetic parameters for catalytic combustion processes involving volatile organic compounds.