The cellular piezoelectret generator (CPG) has drawn considerable attention as an emerging flexible energy harvester because of its advantages of a simple structure, easy assembly, a low cost, and eco-friendliness. To facilitate practical applications, an initial theoretical study of CPGs is presented in this work, in which the output characteristics of CPGs can be optimized through an appropriate choice of parameters, including the electret dielectric permittivity, device structure, polarization process, and external load. A good agreement with experimental results is achieved, verifying the validity of the theoretical study. The reported theory offers a complete interpretation of the dynamic working mechanism of CPGs and provides significant guidance for the design of a CPG with enhanced yield.