화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.40, No.3, 457-463, May, 2016
DOI10.7317/pk.2016.40.3.457  Export Citation
순차적인 마이크로 몰딩 방법을 이용한 다중 분획 입자의 제조
Fabrication of Multicompartment Particles via Sequential Micromolding Method
염수진, 강성민, 김종민, 남진오, 엄나예, 이소희, 이창수†
  • 충남대학교 공과대학 화학공학과
Su-Jin Yeom, Sung-Min Kang, Jongmin Kim, Jin-Oh Nam, Naye Eom, Sohui Lee, and Chang-Soo Lee†
  • Department of Chemical Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea
E-mail:
초록
본 연구는 순차적인 마이크로 몰딩 방법을 이용한 고분자 다중 분획 입자 제조 방법에 관한 것이다. 다중 분획 입자는 poly(dimethylsiloxane)(PDMS) 마이크로 몰드 내로 단량체 혼합물의 주입, 휘발성 용매의 증발, 광중합으로 이루어지는 일련의 과정을 통해 제조한다. 이때, 단량체 혼합물에 포함된 휘발성 용매의 농도에 따라, 다중 분획입자를 구성하는 각 구획의 부피분율을 제어하는 것이 가능하다. 또한 단량체 혼합물의 농도 및 다중 분획 입자 제조공정의 반복횟수에 따라, 단일 입자, 이중 입자, 삼중 입자를 선택적으로 제조가 가능함을 보여준다. 제조한 각각의 다중 분획 입자에 형광염료를 함입하여 특정한 정보를 인코딩한 바코드 입자로써의 활용 가능성을 증명한다. 본 연구에서 제안하는 다중 분획 입자를 제조하기 위한 순차적인 마이크로 몰딩 방법은 쉽고, 빠르며, 고가의 장비를 필요로 하지 않는 장점을 가지며, 제조된 다중 분획 입자는 약물 저장 및 전달 소재, 바이오 센서, 그리고 선택적인 흡착-탈착을 유도할 수 있는 고감도 기능성 재료로서 응용이 가능할 것으로 기대한다.
In this paper, we present a fabrication method of polymeric multicompartment particles via a sequential micromolding process composed of injection of photocurable solution, evaporation of volatile solvent, and photo-polymerization. Depending on the concentration of volatile solvent in photocurable solution, the volume fraction of the multicompartment particles can be controlled. Also, the repetition of the sequential micromolding process with controlled composition of photocurable solution provides controlling the number of compartment in the particles. Based on this principle, we can fabricate single particles, Janus particles and triblock particles with desired fraction of the compartment. In addition, the multicompartment particles are able to be applicable for barcode particles embedding fluorescent dyes at each compartment. The barcode particles encode information about their specific compositions and enable simple identification. These sequential micromolding method for multicompartment particles has several advantages including easy, fast, and cost effective process. We envision that the multicompartment particles have various applications such as drug storage, delivery supporters, biosensors, and advanced materials for inducing highly selective adsorption-desorption.
Keywords:multicompartment particles;information;encoding;micromolding
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