A new method of synthesis based on micro-fluidic continuous coprecipitation has been used to prepare CuO-ZnO-ZrO2 catalyst. The catalytic behavior was then investigated for CO2 hydrogenation into methanol and compared with a CuO-ZnO-ZrO2 catalyst prepared by classical coprecipitation and with the same amount of Cu-0 (30%). The novel synthesis method allows a better repeatability and homogeneity of the catalyst which leads to the best methanol productivity of 486 g(MeOH) kg(cata) (-1) h(-1) at 280 degrees C under 50 bar and a GHSV of 10,000 h(-1). (C) 2015 Elsevier B.V. All rights reserved.