Graphite oxide (GO) has got more and more attention for its excellent performance. However, the desalination of GO dispersions is a challenge because of its easy swelling and electronegativity. A new electrodialysis (ED) system was developed specially by adding an interception medium (IM), to solve the membrane fouling of conventional ED system and achieve efficient desalination. The salt removal rate and efficiency were achieved about 85% and 88%, respectively, for GO by this designed ED system under the optimum conditions. The results showed that the designed ED system was more suitable for the desalination of GO dispersions, which intercepted charged particles and ensured the continuous work of anion exchange membrane (AEM). These results provide important technical basis for a large-scale procedure of GO and the desalination of charged colloid dispersions. (C) 2016 Elsevier B.V. All rights reserved.