A novel strategy for membrane fouling control based on. combination of intermittent gas sparging and transmembrane pressure set-point (TMPsp) for backwashing initiation was assessed at laboratory scale. Ultrafiltration of anaerobic suspensions, complex arid highly concentrated, was carried out at supracritical permeate fluxes and different TMPsp values. Intermittent gas sparging effectively mitigated reversible fouling mainly caused by a cake layer formed of large particles, regardless of the selected TMPsp. In fact, cycle duration increased with dimensionless gas-sparging time (Theta(gs)) and TMIPsp, although this trend diminished with rising permeate flux (J(p)). Additionally, backwashing initiation by TMPsp demonstrated its high effectiveness in preventing residual fouling, independent of the applied conditions (Theta(gs), J, and TMPsp). As a result, high net permeate fluxes were obtained at moderate J and low Theta(gs) values. Therefore, the applied combined strategy is a promising option for reducing gas consumption that should contribute to a sustainable operation of anaerobic membrane bioreactors.