Ticlopidine (Tic) ion selective liquid membrane electrode was constructed from poly (vinyl chloride) containing Tic-tetraphenylborate (Tic-TPB) as the sensing element in the presence of dioctylphthalate (DOP) as the plasticizing solvent mediator. The electrode shows nearly Nernstian response for the drug over the concentration range of 1.0 x 10(-2)-5.0 x 10(-5) M with cationic slope of 58.23 mV per concentration decade, and the response time is very short (<= 10 s). The electrode potential is nearly stable over the pH range 3.8-5.4. The electrode exhibits good selectivity for the Tic with respect to a large number of inorganic ions, amino acids and some pharmaceutical substances. The sensor successfully was used for the determination of Tic in pharmaceutical and biological samples. The average recovery and RSD for the analysis of Tic in pharmaceutical and biological samples using the proposed method obtained 101.04, 98.90% and 1.14, 1.39%, respectively. The results are in good agreement with those obtained by voltammetry method. (C) 2016 Elsevier B.V. All rights reserved.