In gas-condensate reservoirs suffering from condensate banking, the supercritical CO2 injection process is regarded as one of the most effective technical remedies to reduce the liquid formation and achieve higher quality gas production. With proper well configuration and spacing designs, the injected CO2 can decrease the loss of heavy components effectively. The main goal of this study was to minimize the loss of heavy components during CO2 injection by implementing a proper well configuration. The results show that the integration of pressure maintenance and chemical reactions, including reduced viscosity and interfacial tension, improves the C7+ component recovery by 42.9, 49.4, and 49.3% for the base five-spot, inverted five-spot, and line drive cases, respectively. The total recovery is the highest for the line drive pattern with a recovery factor of 72.7%. The results also indicate that there is a critical length maximizing the effect of gas cycling.