Jatropha was identified as a potential feedstock to satisfy off-grid and on-grid energy solutions. However, the potential has been questioned due to agronomic frustrations, the lack of an organized value chain and heavy criticism on biofuels due to emissions triggered by land use change (LUC). To contribute to the realistic integration of Jatropha in rural development, this article proposes a modeling approach to probe the feasibility of Jatropha-based electrification in rural Africa and the layout of such a value chain. A multi-component modeling setup is presented, featuring a life cycle inventory, spatial modeling and the optimization model, OPTIMASS. In this modeling setup, OPTIMASS is parameterized with data regarding the global warming potential and the potential location of each operation in the value chain including cultivation sites and related LUC emissions. This enables OPTIMASS to spatially design the Jatropha-based on-grid and off-grid electrification value chain (i.e. cultivation, transport and storage, biofuel production and electricity generation) in Southern Mali with minimal GWP to reach 10% substitution of fossil fuels for Jatropha in electricity production for a current and two future electricity demand scenarios. Analysis of the optimization results demonstrates that emissions from transporting the oil are lower than LUC emissions per harvestable seed of other sites. Finally, it can be said that harnessing the entirety of the Jatropha value chain is crucial to make it GWP competitive relative to fossil fuels in which the location of plantations is crucial to attain low LUC-related emissions and viable yields. (C) 2016 Elsevier Ltd. All rights reserved.