In this work, external circulation rotating packed bed (EX-RPB) was combined with internal circulation rotating packed bed (IN-RPB) for the preparation of Y-type oxotitanium phthalocyanine nanocrystals (Y-TiOPc NCs) for the first time. The operating conditions in EX-RPB and in IN-RPB were investigated in detail. X-ray diffraction (XRD), transmission electron microscopy (TEM), ultraviolet-visible (UV-vis) absorption spectroscopy analysis, and elemental analysis were performed, and xerographic properties were analyzed, to characterize the products. The experimental results indicated Y-TiOPc NCs with the average size of 6 nm were successfully prepared. The Q-band absorption peak of Y-TiOPc NCs centered at 782 nm, implying their potential application in the xerographic photoreceptors of laser printers. The photoreceptor fabricated with Y-TiOPc NCs exhibited an initial surface potential of 703.56 V, a photosensitivity of 0.166 mu J/cm(2), a residual potential of 26.48 V, and a dark decay rate of 10.64 V/s. This work made a significant improvement to control the crystal form of nanoparticles at a large scale.