Mesoporous aluminosilicate with ZSM-5 structure was synthesized from ZSM-5 nanoclusters and used as support, which possessed strong acidity, large surface areas, and high hydrothermal stability. A series of 0-12 wt % MgO-10 wt % Ni/MAS-24 were prepared via a sol-gel method and characterized by XRD, N-2 adsorption, FT-IR, H-2-TPR, CO2-TPD, UV-vis, TG/DSC, and HRTEM techniques. The effects of catalyst composition and reaction temperature on the catalytic performance in CO2/CH4 reforming were studied. The catalytic stability over 9 wt % MgO-10Ni/MAS-24 for 60 h indicated that the conversion of CH4 and CO2 maintained 93% and 99%, respectively, the selectivity of H-2 and CO for 99% at 800 degrees C, although the conversion of CH4 decreased to 83% in the later 30 h due to high dispersion of Ni particles via synergistic action between MgO and NiO nanoparticles as well as basic effect on the surface, which prevented Ni-0 active particles from aggregating and coke formation during the CH4/CO2 reforming reaction.