We report a facile and controllable approach to design anodic catalysts with different surface morphologies. The RuO2-TiO2 anodes are directly grown in situ on the surface of Ti substrate under certain hydrothermal conditions. X-ray diffraction, field-emission scanning electron microscopy, energy dispersive X-ray spectra, cyclic voltammetry, and linear scanning voltammetry (LSV) were used to scrutinize the electrodes and the electrochemical activity. The experimental results indicate that solvothermal crystallization in the presence of hydrochloric acid plays a critical role in regulating the catalyst size and microstructure during the nucleation and growth process of RuO2-TiO2. The designed RuO2-TiO2/Ti anode with a nano-flowerlike structure displays significantly enhanced activity toward anodic chlorine evolution reaction (CER) compared to the other two morphology anodes. Such excellent performance of RuO2-TiO2/Ti is explained in terms of the small charge transfer resistance and the unique surface structure with more active sites to be utilized during CER.