Soft sensors are used to predict response variables, as these variables are difficult to measure, the prediction models use data of predictors that are relatively easier to obtain. Arranging time-lagged data of predictors and applying the partial least squares (PLS) method to the dataset is a popular approach for extracting the correlation between data of the responses and predictors of the process dynamic. Because irrelevant inputs deteriorate the prediction performance of the soft sensor, the selection of variables in the PLS-based model is a critical step for developing a robust and accurate model. Furthermore, it is necessary to reselect the important predictors of a soft sensor when the operating mode is changed. However, a switch in the operating mode may not be measured, directly. In this study, two statistics are proposed to detect a change of operating mode to enable the reselection of the predictors of the soft sensor. This work involved the development of a soft sensor based on operating data from the industrial ethane removal (de-ethane) process. The changeover of crude oil types cannot be observed from the data of process variables; however, the correlation between input and output variables is significantly affected by the different types of crude oil. The result shows that the use of a soft sensor with online variable reselection is capable of maintaining the accuracy and robustness of the inferential model, effectively. (C) 2016 Elsevier Ltd. All rights reserved.