A simple synthetic autocatalytic replicator is capable of establishing and driving the propagation Of a reaction diffusion front within a 50 mu L syringe. This replicator templates its own synthesis through a 1,3-dipolar cycloaddition reaction between a nitrone component, equipped with a 9-ethynylanthracene optical tag, and a maleimide. Kinetic studies using NMR and UV-vis spectroscopies confirm that the replicator forms efficiently and with high diastereoselectivity, and this replication process brings about a dramatic change in optical properties of the sample a change in the color of the fluorescence in the sample from yellow to blue. The addition of a small amount of the preformed replicator at a specific location within a microsyringe, filled with the reaction building blocks, results in the initiation and propagation of a reaction diffusion front. The realization of a replicator capable of initiating a reaction diffusion front provides a platform, for the examination of interconnected replicating networks under out-of-equilibrium conditions involving diffusion processes.