Distillation is the best option for the separation of hydrocarbon mixtures, unless the boiling points of the constituents are close together. Despite being widely utilized in field applications, the high energy demand of distillation calls for efficient columns in order to save energy. The efficient divided wall column (DWC), diabatic distillation column, and internally heat-integrated distillation column (HIDiC) are introduced here, and the design and control of the columns are briefly reviewed. The practical applications of the columns in the processes of natural gas production from raw gas drawn from underground and benzene separation from naphtha reformate are presented to show the energy-saving performance of the energy-efficient distillation columns. The side-rectifier DWC reduced the heating duty of the conventional system by 5.9%, and provided a compact construction, replacing the three-column conventional system with a single column suitable for offshore application. Moreover, the controllability of DWC was improved by utilizing the side-rectifier. The benzene removal process utilizing the extended DWC lowered the heating duty of the whole conventional process by 56.8%.