화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.24, No.9, 767-772, September, 2016
DOI10.1007/s13233-016-4111-8  Export Citation
Antiangiogenic actions of heparin derivatives for cancer therapy
Hae Hyun Hwang, and Dong Yun Lee†
  • Department of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, and Institute of Nano Science & T, Hanyang University, Seoul, 04763, Korea
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Heparin is widely used as an anticoagulant agent in clinical medication. Recent studies have reported that heparin could have anticancer effects due to its interaction with angiogenesis-related molecules, meaning that it could reduce the formation of new blood vessels and tumorigenesis in the body. However, when heparin is administered for long periods, it can cause heparin-induced thrombocytopenia (HIT) and bleeding due to its anticoagulant activity. To overcome this limitation, heparin derivatives have been developed by modification of their structure or by conjugation with functional groups. Here we reviewed several kinds of heparin derivatives using bile acids, proteins, and metal nanoparticles in terms of angiogenesis. These heparin derivatives are promising candidates for new anticancer treatments.
Keywords:heparin derivatives;anticancer;bile acid;protein;metal nanoparticle
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