Engineered self-expander hydrogel for sustained release of drug molecules

Jieun Kim; Jangsun Hwang; Youngmin Seo; Yeonho Jo; Jaewoo Son; Taejong Paik; Jonghoon Choi

Journal of Industrial and Engineering Chemistry, Vol.42, 121-125, October, 2016

DOI10.1016/j.jiec.2016.07.033 Export Citation

Engineered self-expander hydrogel for sustained release of drug molecules

Jieun Kim, Jangsun Hwang, Youngmin Seo, Yeonho Jo, Jaewoo Son, Taejong Paik^†, and Jonghoon Choi^†

School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea

E-mail:,

We synthesized a copolymer hydrogel composed of methyl methacrylate and N-vinyl-2-pyrrolidone and evaluated the in vitro release of the anticancer drug doxorubicin from this self-expanding hydrogel, under physiological conditions. The degree of expansion of the self-expanding copolymer was measured in various solutions. We induced drug adsorption into the methyl methacrylate and N-vinyl-2-pyrrolidone hydrogel by self-expansion, promoted by osmotic pressure. The antitumor effects of the released drug molecules were evaluated in MDA-MB-231 breast carcinoma cells. In conclusion, we provide evidence that this drug-containing self-expanding hydrogel may have the potential for biomedical applications including as an implant in tissue areas that require both physical support and anti-inflammatory drug treatment.

Keywords:Hydrogel;Self-expander;Breast cancer;Doxorubicin

[References]

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Xuequan L, Maolin Z, Jiuqiang L, Hongfei H, Radiat. Phys. Chem., 57, 477 (2000)
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Lee WF, Chiang WH, J. Appl. Polym. Sci., 91(4), 2135 (2004)
Jaiswal M, Dinda AK, Gupta A, Koul V, Biomed. Mater., 5, 065014 (2010)
Middleton JC, Tipton AJ, Biomaterials, 21, 2335 (2000)
Lowman AM, Peppas NA, Polymer, 41(1), 73 (2000)
Liu SX, Fang Y, Hu DD, Gao GL, Ma JB, J. Appl. Polym. Sci., 82(3), 620 (2001)
Bekturov EA, Frolova VA, Bimendina LA, Macromol. Chem. Phys., 200, 431 (1999)
Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA, Int. J. Pharm., 15, 25 (1983)
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[Referenced By]

[1] Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, Bannerjee SK, Int. J. Pharm. Invest., 2, 2 (2012)

[2] Peppas NA, Bures P, Leobandung W, Ichikawa H, Eur. J. Pharm. Biopharm., 50, 27 (2000)

[3] Lee SC, Kwon IK, Park K, Adv. Drug Deliv. Rev., 65, 17 (2013)

[4] Benoit DS, Nuttelman CR, Collins SD, Anseth KS, Biomaterials, 27, 6102 (2006)

[5] Khetani SR, Bhatia SN, Curr. Opin. Biotechnol., 17, 524 (2006)

[6] Perez JPH, Lopez-Cabarcos E, Lopez-Ruiz B, Biomol. Eng., 23, 233 (2006)

[7] Wiese KG, J. Craniomaxillofac. Surg., 21, 309 (1993)

[8] Wiese KG, Heinemann DE, Ostermeier D, Peters JH, J. Biomed. Mater. Res., 54, 179 (2001)

[9] Bacskulin A, Vogel M, Wiese KG, Gundlach K, Hingst V, Guthoff R, Graefe Arch. Clin. Exp. Ophthalmol., 238, 24 (2000)

[10] Gundlach KK, Guthoff RF, Hingst VH, Schittkowski MP, Bier UC, Plast. Reconstr. Surg., 116, 1214 (2005)

[11] Ronert MA, Hofheinz H, Manassa E, Asgarouladi H, Olbrisch RR, Plast. Reconstr. Surg., 114, 1025 (2004)

[12] Kobus KF, J. Plast. Reconstruct. Aesthet. Surg., 60, 414 (2007)

[13] Sperling LH, Am. Chem. Soc., 3 (1994)

[14] Xuequan L, Maolin Z, Jiuqiang L, Hongfei H, Radiat. Phys. Chem., 57, 477 (2000)

[15] Zhang J, Peppas NA, Macromolecules, 33(1), 102 (2000)

[16] Lee WF, Chiang WH, J. Appl. Polym. Sci., 91(4), 2135 (2004)

[17] Jaiswal M, Dinda AK, Gupta A, Koul V, Biomed. Mater., 5, 065014 (2010)

[18] Middleton JC, Tipton AJ, Biomaterials, 21, 2335 (2000)

[19] Lowman AM, Peppas NA, Polymer, 41(1), 73 (2000)

[20] Liu SX, Fang Y, Hu DD, Gao GL, Ma JB, J. Appl. Polym. Sci., 82(3), 620 (2001)

[21] Bekturov EA, Frolova VA, Bimendina LA, Macromol. Chem. Phys., 200, 431 (1999)

[22] Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA, Int. J. Pharm., 15, 25 (1983)

[23] Hayashi T, Kanbe H, Okada M, Suzuki M, Ikeda Y, Onuki Y, Kaneko T, Sonobe T, Int. J. Pharm., 304, 91 (2005)