A heterogeneous Fenton-like catalyst was used for the oxidation of Bisphenol A (BPA), which is a typical endocrine disruptor. A simple semi-empirical kinetic equation was developed to define the effects of experimental conditions (initial concentration of H2O2, initial concentration of BPA, temperature and the catalyst loading) on the reaction rate. The plausible pathway of the degradation process was proposed. A pseudo-first-order reaction rate expression with respect to BPA concentration was developed to fit all data for these experiments, and the equation of k(obs) (observed rate constant) was obtained with the apparent activation energy of 42.2 kJ/mol. In order to reduce the operational cost, the values of parameters (temperature, initial concentration of H2O2 and pH) that optimize the catalytic performance were studied by means of a response surface methodology. Finally, a plausible mechanism was proposed on the basis of kinetics and optimization studies, which illustrates the reaction process and optimization in a microscopic view. (C) 2016 Elsevier B.V. All rights reserved.