폴리우레탄-폴리비닐알콜 블렌드의 특성 및 혈소판점착 거동

유영미; 신재섭; 김승수

Polymer(Korea), Vol.23, No.2, 312-319, March, 1999

Export Citation

폴리우레탄-폴리비닐알콜 블렌드의 특성 및 혈소판점착 거동

Preparation and Characterization of Polyurethane-Poly(vinyl alcoho) Polymer Blends and Their Platelet Adhesion

유영미, 신재섭, 김승수

초록

폴리우렌탄(PU)과 폴리비닐알콜(PVA)의 고분자 블렌드를 제조하고 물성 및 혈소판 부착서을 조사하였다. 고분자 블렌드의 물리적 특서을 조사하기 위하여 물흡수도, 수접촉각, 인장강도 및 연신율 등을 조사하였고, PU와 PVA의 상용성을 조사하기 위하여 파단면을 주사전자현미경 (SEM)으로 관찰하였다. 또한 표면에 노출된 PVA양의 변화를 조사하기 위하여 trifluoroacetic anhydride를 반응시켜 ESCA로 분석하였으며 혈소판 점착실험을 행하고 SEM을 이용하여 부착된 혈소판의 형태와 수를 측정하였다. PU/PVA 고분자 블렌드에서 PVA 양이 증가함에 따라 기계적 가도는 낮아지고, 물흡수도는 증가하였으며, 수접촉각은 점차로 감소하였다. 고분자 블렌드는 PU/PVA 사이의 계면장력 차이에 의하여 상용성은 좋지 않았으며 표면에 노출된 수산기의 양은 PVA양이 증가할수록 위로 볼록한 고선 형태로 증가하였다. 고분자 블렌드 내에 포함된 PVA의 양에 따라 혈소판 점착 경향을 조사한 결과, 10-50 wt%의 PVA를 포함한 고분자 블렌드에서 혈소판의 점착이 가장 적고 혈소판의 형태 변화가 가장 낮게 관찰되었다. 이와 같은 경향은 재료 표면에서 섬모운동을 하는 PVA의 밀도와 상관이 있는 것으로 사료된다.

Polymer blends consisted of polyurethan (PU) and poly(vinyl alcohol) (PVA) were prepared and then the dependences of their physical properties and platelet adhesion upon the mixing ratio were characterized. The water absorbency of the polymer blends increased and their water contact angles decreased with the increase in the amount of PVA in the polymer bblends. The tensile strength and elongation of the polymer blends were deteriorated by the increase of PVA amount. According to the observation of the fractured surfaces, the miscibility of PU and PVA was not good presumable due to the large difference of surface tension between them. The amounts of hydroxyl groups exposed on the surfaces of the polymer blends increased hyperbloically with the increase in the amount of PVA in them. According to the results ofexperiments of platelet adhesion. platelets were less adhered on the polymer blends with 10-50 wt% PVA and the morphological change of the platelets adhered on them was less, comparing to PU, PVA, and the other polymer blends. It may be correlated with the amount of PVA molecules exposed on the surfaces.

Keywords:polymer blend;polyurethane;poly(vinyl alcohol);platelet adhesion

[References]

O'Donnell TF, Mackey W, McCullough JL, Maxwell SL, Farber SP, Deterling RA, Callow AD, J. Vasc. Surg., 1, 136 (1984)
Tsuruta T, Hayashi T, Kataoka K, Ishihara K, Kimura Y, "Biomedical Applications of Polymeric Materials," p. 90, CRC Press (1993)
Han DK, Jeong SY, Ahn KD, Kim YH, Min BG, J. Biomater. Sci.-Polym. Ed., 4, 579 (1993)
Ishihara K, Oshida H, Endo Y, Ueda T, Watanabe A, Nakabayashi N, J. Biomed. Mater. Res., 26, 203 (1992)
Marconi W, Martinelli A, Piozzi A, Zane D, Macromol. Chem. Phys., 195, 875 (1994)
Okano T, Nishiyama S, Shinohara I, Akaike T, Sakurai Y, Kataoka K, Tsuruta T, J. Biomed. Mater. Res., 15, 393 (1981)
Cimmino S, Martuscelli E, Silvestre C, Barbucci R, Magnani A, Tempesti F, J. Appl. Polym. Sci., 47, 631 (1993)
Marconi W, Calloppa A, Martinelli A, Piozzi A, Biomaterials, 16, 449 (1995)
Walker FJ, Esmon CT, Biochem. Biophys. Res. Commun., 83, 1339 (1978)
Ito Y, Sisido M, Imanish Y, J. Biomed. Mater. Res., 20, 1157 (1987)
Blezer R, Fouache B, Willems GM, Lindhout T, J. Biomed. Mater. Res., 37, 108 (1997)
Andrade JD, Med. Instrum., 7, 110 (1973)
Sheu MS, Hoffman AS, Ratner BD, Feijen J, Harris JM, J. Adhes. Sci. Technol., 7, 1065 (1993)
Desai NP, Habbel JA, Biomaterials, 12, 144 (1991)
Mori Y, Nagaok S, Takiuchi H, Noguchi N, Tanzawa H, Noishiki Y, Trans. Am. Soc. Artif. Intern. Organs., 28, 459 (1982)
Nagaoka S, Nakao A, Biomaterials, 11, 119 (1990)
Dickie RA, Hammond JS, Devries JE, Holubka JW, Anal. Chem., 54, 2045 (1982)
Shin YC, Han DK, Kim YH, Kim SC, Polym.(Korea), 16(5), 520 (1992)
Kim SS, Kim HW, Yuk SH, Oh SY, Park PK, Lee HB, Biomaterials, 17, 813 (1995)

[Referenced By]

[1] O'Donnell TF, Mackey W, McCullough JL, Maxwell SL, Farber SP, Deterling RA, Callow AD, J. Vasc. Surg., 1, 136 (1984)

[2] Tsuruta T, Hayashi T, Kataoka K, Ishihara K, Kimura Y, "Biomedical Applications of Polymeric Materials," p. 90, CRC Press (1993)

[3] Han DK, Jeong SY, Ahn KD, Kim YH, Min BG, J. Biomater. Sci.-Polym. Ed., 4, 579 (1993)

[4] Ishihara K, Oshida H, Endo Y, Ueda T, Watanabe A, Nakabayashi N, J. Biomed. Mater. Res., 26, 203 (1992)

[5] Marconi W, Martinelli A, Piozzi A, Zane D, Macromol. Chem. Phys., 195, 875 (1994)

[6] Okano T, Nishiyama S, Shinohara I, Akaike T, Sakurai Y, Kataoka K, Tsuruta T, J. Biomed. Mater. Res., 15, 393 (1981)

[7] Cimmino S, Martuscelli E, Silvestre C, Barbucci R, Magnani A, Tempesti F, J. Appl. Polym. Sci., 47, 631 (1993)

[8] Marconi W, Calloppa A, Martinelli A, Piozzi A, Biomaterials, 16, 449 (1995)

[9] Walker FJ, Esmon CT, Biochem. Biophys. Res. Commun., 83, 1339 (1978)

[10] Ito Y, Sisido M, Imanish Y, J. Biomed. Mater. Res., 20, 1157 (1987)

[11] Blezer R, Fouache B, Willems GM, Lindhout T, J. Biomed. Mater. Res., 37, 108 (1997)

[12] Andrade JD, Med. Instrum., 7, 110 (1973)

[13] Sheu MS, Hoffman AS, Ratner BD, Feijen J, Harris JM, J. Adhes. Sci. Technol., 7, 1065 (1993)

[14] Desai NP, Habbel JA, Biomaterials, 12, 144 (1991)

[15] Mori Y, Nagaok S, Takiuchi H, Noguchi N, Tanzawa H, Noishiki Y, Trans. Am. Soc. Artif. Intern. Organs., 28, 459 (1982)

[16] Nagaoka S, Nakao A, Biomaterials, 11, 119 (1990)

[17] Dickie RA, Hammond JS, Devries JE, Holubka JW, Anal. Chem., 54, 2045 (1982)

[18] Shin YC, Han DK, Kim YH, Kim SC, Polym.(Korea), 16(5), 520 (1992)

[19] Kim SS, Kim HW, Yuk SH, Oh SY, Park PK, Lee HB, Biomaterials, 17, 813 (1995)