중합체 용액내에서 침전주합법에 의한 Poly(benzyl methacrylate) Microsphere의 제조

조석형; 김공수; 김태경; 김영준; Suk Hyeong Cho; Kong Soo Kim; Tae Kyoung Kim; Young Jun Kim

Polymer(Korea), Vol.23, No.4, 487-492, July, 1999

Export Citation

중합체 용액내에서 침전주합법에 의한 Poly(benzyl methacrylate) Microsphere의 제조

Preparation of Poly(benzyl methacrylate) Microspheres by Precipitation Polymerization in Polymer Solution

조석형^†, 김공수¹, 김태경¹, 김영준²

혜전대학 신소재응용화학과
¹충북대학교 화학공학부
²청운대학교 신소재응용화학과

Suk Hyeong Cho^†, Kong Soo Kim¹, Tae Kyoung Kim¹, and Young Jun Kim²

Department of Hi-tech Mateirals and Applied Chemistry, Hyejeon College, Honsung-eup 350-800, Korea
¹Department of Industrial and Engineering Chemistry, Chngbuk National University, CheongJu 350-763, Korea
²Department of Materials and Applied Chemistry, Chungwoon University, Honsung-eup 350-800, Korea

E-mail:

초록

Poly(benzyl methacrylate) (PBMA) microsphere는 benzyl methacrylate를 폴리아크릴산/에탄올 용액 중에서 침전중합시켜 제조하였다. 폴리아크릴산의 농도, 폴리아크릴산과 단량체의 비율 및 용매의 성질에 따라 다른 크기의 PBMA microsphere를 합성하였다. 폴리아크릴산 용액의 농도가 증가함에 따라 microsphere의 입자크기가 작아지는 경향을 나타내었다. 또한 microsphere의 입자크기는 0.1 ㎛에서 0.35 ㎛까지 중합조건에 따라 조절할 수 있었다.

Poly(benzyl methacrylate) (PBMA) microsphere was prepared by precipitation polymerization of benzyl methacrylate in poly(acrylic acid)/ethanol solution. Microspheres with various size were obtained by changing the concentration of poly(acrylic acid), monomer and nature of solvents. The particle size PBMA microsphere was decreased with increasing the concentration of poly(acrylic acid) and increased with that of nomomer. With increasing solubility parameter of solvents, the particle size was decreased. The size of PBMA microspheres was controlled by experimental conditions from 0.1 ㎛ to 0.35 ㎛.

Keywords:microsphere;precipitation polymerization;methacrylate particle size

[References]

Baker W, Ind. Eng. Chem., 41, 511 (1949)
Hoffmann M, Makromol. Chem., 175, 613 (1974)
Forget J, Booth C, J. Polym. Sci. B: Polym. Phys., 17, 1403 (1979)
Medalia A, Koithoff I, J. Polym. Sci., 6, 433 (1951)
Price C, Forget J, Booth C, Polymer, 18, 527 (1977)
Gram J, J. Coat. Technol., 51, 34 (1979)
Willmott N, Chen Y, Florence AT, J. Control. Release, 8, 103 (1988)
Gupta PK, Gallo JM, Hung CT, Perrier DG, Drug Del. Ind. Pharm., 13, 1471 (1987)
Kim KS, Cho SH, Shin JS, Polym. J., 25, 847 (1993)
Kim KS, Cho SH, Shin JS, Polym. J., 27, 508 (1995)
Ma GH, Fukutomi T, Morone N, J. Colloid Interface Sci., 168(2), 393 (1994)
Basedow AM, Ebert K, Adv. Polym. Sci., 22, 84 (1977)
Di Silvio L, Biomaterials, 15, 921 (1994)
Shahara M, Meshulam H, Margel S, J. Polym. Sci. A: Polym. Chem., 24, 203 (1986)
Yokoyama M, J. Control. Release, 11, 269 (1989)
Yokoyama M, Cancer Res., 50, 1695 (1990)
Cho SH, Kim KS, Kang JK, Cho BH, Polym.(Korea), 18(5), 877 (1994)

[1] Baker W, Ind. Eng. Chem., 41, 511 (1949)

[2] Hoffmann M, Makromol. Chem., 175, 613 (1974)

[3] Forget J, Booth C, J. Polym. Sci. B: Polym. Phys., 17, 1403 (1979)

[4] Medalia A, Koithoff I, J. Polym. Sci., 6, 433 (1951)

[5] Price C, Forget J, Booth C, Polymer, 18, 527 (1977)

[6] Gram J, J. Coat. Technol., 51, 34 (1979)

[7] Willmott N, Chen Y, Florence AT, J. Control. Release, 8, 103 (1988)

[8] Gupta PK, Gallo JM, Hung CT, Perrier DG, Drug Del. Ind. Pharm., 13, 1471 (1987)

[9] Kim KS, Cho SH, Shin JS, Polym. J., 25, 847 (1993)

[10] Kim KS, Cho SH, Shin JS, Polym. J., 27, 508 (1995)

[11] Ma GH, Fukutomi T, Morone N, J. Colloid Interface Sci., 168(2), 393 (1994)

[12] Basedow AM, Ebert K, Adv. Polym. Sci., 22, 84 (1977)

[13] Di Silvio L, Biomaterials, 15, 921 (1994)

[14] Shahara M, Meshulam H, Margel S, J. Polym. Sci. A: Polym. Chem., 24, 203 (1986)

[15] Yokoyama M, J. Control. Release, 11, 269 (1989)

[16] Yokoyama M, Cancer Res., 50, 1695 (1990)

[17] Cho SH, Kim KS, Kang JK, Cho BH, Polym.(Korea), 18(5), 877 (1994)