Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

Pan J; Harriss BI; Chan CF; Jiang LJ; Tsoi TH; Long NJ; Wong WT; Wong WK; Wong KL

Inorganic Chemistry, Vol.55, No.14, 6839-6841, 2016

DOI10.1021/acs.inorgchem.6b01159 Export Citation

Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

Pan J, Harriss BI, Chan CF, Jiang LJ, Tsoi TH, Long NJ, Wong WT, Wong WK, Wong KL

A water-soluble bimetallic normal ("cold") and radiochemical ("hot") gallium-porphyrin-ruthenium-bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. (68)GaporRu-1 is demonstrated to be a potential Multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.