The removal of a xenobiotic (4-chlorophenol) from contaminated water was investigated in a simulated continuous two-phase partitioning bioreactor (C-TPPB), fitted with coiled tubing comprised of a specifically-selected extruded polymer, Hytrel 8206. Wastewater flowed inside the tubing, the pollutant diffused through the tubing wall, and was removed in the aqueous bioreactor phase at typical biological removal rates in the C-ITPB simulated by varying aqueous phase throughput to the reactor. Operating over a range of influent substrate concentrations,(500-1500 mg L-1) and hydraulic retention times in the tubing (4-8 h), overall mass transfer coefficients were 1.7-3.5 x 10(-7) m s(-1), with the highest value corresponding to the highest tubing flow rate. Corresponding mass transfer rates are of the same order as biological removal rates, and thus do not limit the removal process. The C-TPPB showed good performance over all organic and hydraulic loading ranges, with removal efficiencies of 4CP in the tubing wastewater stream always >= 96%. Additionally, the presence of the Hytrel tubing was able to buffer increases in organic loading to the hybrid system, enhancing overall process stability. Biological testing of the C-TPPB confirmed the abiotic test results demonstrating even higher 4-chlorophenol removal efficiency (similar to 99%) in the tubing stream. (C) 2016 Elsevier B.V. All rights reserved.