This article presents studies on the drying kinetics of latexes with particles made progressively softer by adding increasing amounts of a plasticizer, in relation to speeds of horizontal drying fronts and particle deformation mechanisms. Global drying rates were measured by gravimetry, and speeds of the horizontal fronts were recorded using a video camera and image processing. Particle deformation mechanisms were inferred using the deformation map established by Routh and Russel (RR). This required precise measurements of the rheological properties of the polymers using a piezorheometer. The results show that latexes with softer particles dry slowly, but in our systems, this is not due to skin formation. A correlation between global drying rates and speeds of horizontal fronts could be established and interpreted in terms of the evolution of mass transfer coefficients of water in different areas of the drying system. The speeds of the horizontal drying fronts were compared with the RR model. A remarkable qualitative agreement of the curve shapes was observed; however, the fit could not be considered good. These results call for further research efforts in modeling and simulation.