초임계 용매내에서 생분해성 Poly(lactide-co-glycolide)공중합체의 혼합물 밀도 측정

변헌수; Hun-Soo Byun

Polymer(Korea), Vol.24, No.4, 505-512, July, 2000

Export Citation

초임계 용매내에서 생분해성 Poly(lactide-co-glycolide)공중합체의 혼합물 밀도 측정

Mixture Density Measurement of Biodegradable Poly(lactide-co-glycolide) Copolymer in Supercritical Solvents

변헌수

여수대학교 생명공ㆍ화학공학부

Hun-Soo Byun

Lab. of Applied Thermodynamics and Separation Process System, Division of Biotechnology and Chemical Engineering, Yosu National University, Yosu, Chonnam 550-749, Korea

초록

본 연구는 초임계 용매인 CO₂, CHF₃ 및 CHCIF₂내에서 poly(lactic-co-glycolide)[PLGA] 용액과의 혼합물 밀도를 측정하였다. 초임계 용매와 poly(lactic acid) [PLA] 및 PLGA간의 혼합물 밀도는 온도 27∼100℃와 압력 3000bar까지 실험하여 나타내었다. [PLGA_x의 X는 0∼50mol% 범위에 대한 glycolide의 몰농도이다]. PLA-CO₂ 혼합물은 약 1430 bar 이내에서, PLA-CHF₃계는 700 bar이하에서, PLA-CHCIF₃계는 100bar이하에서 각각 용해되었다 이때 온도범위는 27∼93℃이며, 혼합물 밀도는 1.084∼1.334g/cm³ 범위에서 나타났다. PLGA₁₅ 공중합체-CO₂ 혼합물은 약 1900 bar 이하에서 용해되었으며, 이때 혼합물 밀도는 37∼92℃에서 1.158∼1.247g/cm³으로 나타났다. PLGA₂₅공중합체-CO₂계는 약 2390 bar이하에서, PLGA₂₅-CIF₃계에 대해서는 1470 bar이하에서, PLGA₂₅-CIF₃계에 대해서는 118 bar 이하에서 각각 용해되었으며, 혼합물 밀도는 29∼81℃사이에서 1.154∼1.535g/cm³로 나타났다. PLGA₅₀-CO₂계는 240℃, 3000 bar내에서는 용해되지 않았으며, 반면 PLGA₅₀과 CHCIF₂계는 glycolide농도가 증가함에 따라 혼합물 밀도가 증가하였다.

The mixture density dara for poly(lactide-co-glycolide) [PLGA] with supercritical CO₂. CHF₃ and CHCIF₂ were obtained in the temperature range of 27 to 100℃ and at pressures as high as 3000bar(PLGAx, where the molar concentration of glycolide in the backbone, x, range from 0 to 50mol%). The PLA-CO₂, PLA-CHF ₃, and PLA-CHClF ₂ systems dissolve in the pressure less than 1430, below 700, and below 100bar, respectively. The mixture density shows from 1.084 to 1.334g/cm³ at temperatures from 27 to 93℃. The PLGA₁₅-CO₂ mixture dissolves at pressures of below 1900 bar and the mixture density is in the range of 1.158 to 1.247g/cm³ at temperatures between 37 and 92℃. The solubilities of the PLGA₂₅ for CO₂, CHF₃, and CHCIF₂ are shown to pressure as high as 2390,1470, and 118bar, respectively, and the mixture density exhibits from 1.154 to 1.535g/cm³ at temperatures from 29 to 81 ℃. The PLGA₅₀-CO₂ system does not dissolve at 240℃ and 3000bar while the PLGA₅₀-CHCIF₂ does easily at 50℃ and 100 bar. The mixture density for the PLGA-CHCIF₂ system increases even at low pressures as the glycolide molar concentration increases.

Keywords:poly(lactide-co-glycolide) copolymer;mixture density;supercritical solvents

[References]

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[2] Middleton JC, Tipton AJ, "Medical Plastics and Biomaterlas Magazine," March/April, 1998 (1998)

[3] Hile DD, Pishko MV, Macromol. Rapid Commun., 20, 511 (1999)

[4] Mandel FS, "Processing of Biosorable Polymers via Supercritical Fluid," Ferro Corporation, USA, EEC, Japan, 1999 (1999)

[5] Kiran E, Gokmenoglu Z, J. Appl. Polym. Sci., 58(12), 2307 (1995)

[6] Yeo SD, Kiran E, J. Supercrit. Fluids, 15(3), 261 (1999)

[7] Byun HS, Kim CB, J. Korean Ind. Eng. Chem., 9(3), 424 (1998)

[8] Byun HS, Jeon NS, Fluid Phase Equilib., 167(1), 113 (2000)

[9] Byun HS, Todd TP, McHugh MA, J. Chem. Eng. Data, accepted (2000)

[10] Meyer CW, Morrison G, J. Chem. Eng. Data, 36, 409 (1991)

[11] Miller KJ, Savchik JA, J. Am. Chem. Soc., 101, 7206 (1979)

[12] Christensen JJ, Post ME, McFall TA, Izatt RM, Thermochim. Acta, 50, 73 (1981)

[13] Christensen JJ, Christensen SP, Schofield RS, Faux PW, Harding PR, Izatt RM, Thermochim. Acta, 67, 315 (1983)

[14] Izatt RM, Schofield RS, Faux PW, Harding PR, Christensen SP, Christensen JJ, Thermochim. Acta, 68, 223 (1983)

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[16] Noles JR, Zollweg JA, J. Chem. Eng. Data, 37, 306 (1992)

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[18] Meilchen MA, Hasch BM, McHugh MA, Macromolecules, 24, 4874 (1991)

[19] Meilchen MA, Hasch BM, Lee SH, McHugh MA, Polymer, 33, 1922 (1992)

[20] Haschets CW, Blackwood TA, Shine AD, Polym. Prepr. Am. Chem. Soc. Division Polym. Chem., 34, 602 (1993)

[21] Haschetz CW, Shine AD, Macromolecules, 26, 5052 (1993)

[22] Pratt JA, Lee SH, McHugh MA, J. Appl. Polym. Sci., 49, 953 (1993)

[23] Hasch BM, Meilchen MA, Lee SH, McHugh MA, J. Polym. Sci. B-Polym. Phys., 31, 429 (1993)

[24] McHugh MA, Krukonis VJ, "Supercritical Fluid Extraction: Principles and Practice," 2nd Ed., Butterworth, Stoneham, MA, 1994 (1994)