Pluronic mimicking fluorescent carbon nanoparticles conjugated with doxorubicin via acid-cleavable linkage for tumor-targeted drug delivery and bioimaging

Eun Bi Kang; Shazid Md. Sharker; Insik In; Sung Young Park

Journal of Industrial and Engineering Chemistry, Vol.43, 150-157, November, 2016

DOI10.1016/j.jiec.2016.08.001 Export Citation

Pluronic mimicking fluorescent carbon nanoparticles conjugated with doxorubicin via acid-cleavable linkage for tumor-targeted drug delivery and bioimaging

Eun Bi Kang¹, Shazid Md. Sharker², Insik In^{3, 4}, and Sung Young Park^{1, 4, †}

¹Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea
²Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea
³Department of Polymer Science and Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea
⁴Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea

E-mail:

Fluorescent carbon nanoparticles based target drug delivery with bio-imaging systems offer tremendous scope for future. We described Pluronic mimicking fluorescent nanoparticles (Plu-FNPs) surface decorated doxorubicin (DOX) via acid-cleavable hydrazone linkages with tumor target folic acid (FA) [Plu-FNPs-FA-DOX]. The acid labile of hydrazine linkage to DOX can easily break off by controlled pH inducing release of conjugated DOX at site of over-expressed folate receptors (FR). This nanoparticle system can deliver DOX to the target FR and trace the delivery pathway of cancer cells. The approaching platform demonstrates the selectivity and sensitivity of molecular targets, thereby able to maximize the therapeutic efficiency.

Keywords:Fluorescent carbon nanoparticles;Folic acid;Doxorubicin;Target delivery;Bioimaging;Pluronic

[References]

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Kang EB, Lee JE, Jeong JH, Lee G, In I, Park SY, J. Ind. Eng. Chem., 33, 336 (2016)
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Patra S, Roy E, Madhuri R, Sharma PK, Biomater. Sci., 4, 418 (2016)
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Sharker SM, Khatun M, Uddin N, Hasan MS, Chakma S, Rahman AA,, Curr. Drug Ther., 4, 144 (2009)
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[Referenced By]

[1] Faraji AH, Wipf P, Bioorg. Med. Chem., 17, 2950 (2009)

[2] LaVan DA, Lynn DM, Langer R, Nat. Rev. Drug Discov., 1, 77 (2002)

[3] Kang EB, Lee JE, Jeong JH, Lee G, In I, Park SY, J. Ind. Eng. Chem., 33, 336 (2016)

[4] Yoo HS, Lee KH, Oh JE, Park TG, J. Control. Release, 68, 419 (2000)

[5] Patra S, Roy E, Madhuri R, Sharma PK, Biomater. Sci., 4, 418 (2016)

[6] Sharker SM, Kim SM, Lee JE, Choi KH, Shin G, Lee S, Lee KD, Jeong JH, Lee H, Park SY, J. Control. Release, 217, 211 (2015)

[7] Kim J, Lee JE, Lee SH, Yu JH, Lee JH, Park TG, Hyeon T, Adv. Mater., 20(3), 478 (2008)

[8] Sharker SM, Khatun M, Uddin N, Hasan MS, Chakma S, Rahman AA,, Curr. Drug Ther., 4, 144 (2009)

[9] Sharker SM, Kim SM, Lee JE, Jeong JH, In I, Lee KD, Lee H, Park SY, Nanoscale, 7, 5468 (2015)

[10] Jeong CJ, Lee G, In I, Park SY, Luminescence, 31, 897 (2015)

[11] Wang H, Shen J, Li Y, Wei Z, Cao G, Gai Z, Hong K, Banerjee P, Zhou S, Biomater. Sci., 2, 915 (2014)

[12] Sharker SM, Kim SM, Kim SH, In I, Lee H, Park SY, J. Mater. Chem. B, 3, 5833 (2015)

[13] Misra SK, Ohoka A, Kolmodin NJ, Pan D, Mol. Pharm., 12, 375 (2015)

[14] Leamon CP, Reddy JA, Adv. Drug Deliv. Rev., 56, 1127 (2004)

[15] Hruby M, Konak C, Ulbrich K, J. Control. Release, 103, 137 (2005)

[16] Lee Y, Park SY, Mok H, Park TG, Bioconjugate Chem., 19, 525 (2008)

[17] Sharker SM, Lee JE, Kim SH, Jeong JH, In I, Lee H, Park SY, Biomaterials, 61, 229 (2015)

[18] Gou P, Liu W, Mao W, Tang J, Shen Y, J. Mater. Chem. B, 1, 284 (2013)

[19] Bae Y, Jang WD, Nishiyama N, Fukushima S, Kataoka K, Mol. Biosyst., 1, 242 (2005)

[20] Bertrand N, Wu J, Xu X, Kamaly N, Farokhzad OC, Adv. Drug Deliv. Rev., 66, 2 (2014)

[21] Kamaly N, Xiao Z, Valencia PM, Radovic-Moreno AF, Farokhzad OC, Chem. Soc. Rev., 41, 2971 (2012)

[22] Sharker SM, Jeong CJ, Kim SM, Lee JE, Jeong JH, In I, Lee H, Park SY, Chem. Asian J., 9, 2921 (2014)

[23] Pourjavadi A, Tehrani ZM, Jokar S, J. Ind. Eng. Chem., 28, 45 (2015)

[24] Cho K, Wang X, Nie S, Chen Z, Shin DM, Clin. Cancer Res., 14, 1310 (2008)

[25] Abdel-Mottaleb MM, Beduneau A, Pellequer Y, Lamprecht A, Int. J. Pharm., 494, 471 (2015)

[26] Kumar R, Kulkarni A, Nagesha DK, Sridhar S, Theranostics, 2, 714 (2012)

[27] Li X, Shao J, Qin Y, Shao C, Zheng T, Ye L, J. Mater. Chem., 21, 7966 (2011)

[28] Rouhollah K, Pelin M, Serap Y, Gozde U, Ufuk G, J. Pharm. Sci., 102, 1825 (2013)

[29] Nguyen DH, Bae JW, Choi JH, Lee JS, Park KD, J. Bioact. Compat. Polym., 28, 341 (2013)

[30] Unsoy G, Khodadust R, Yalcin S, Mutlu P, Gunduz U, Eur. J. Pharm. Sci., 62, 243 (2014)

[31] Zhang XJ, Chen DW, Ba S, Zhu J, Zhang J, Hong W, Zhao XL, Hu HY, Qiao MX, Biomacromolecules, 15(11), 4032 (2014)

[32] Kim K, Lee CS, Na K, Chem. Commun., 52, 2839 (2016)