화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korea-Australia Rheology Journal, Vol.28, No.4, 315-326, November, 2016
DOI10.1007/s13367-016-0032-5  Export Citation
Hydrodynamic extensional stress during the bubble bursting process for bioreactor system design
Thanh Tinh Tran, Eun Gyo Lee1, In Su Lee2, Nam Sub Woo3, Sang Mok Han3, Young Ju Kim3, †, and Wook Ryol Hwang†
  • School of Mechanical and Aerospace Engineering, Research Center for Aircraft Parts Technology (ReCAPT), Gyeongsang National University, Jinju 52828, Republic of Korea
  • 1Biotechnology Process Engineering Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea
  • 2CNS Co., Ltd., Daejeon 34369, Republic of Korea
  • 3Pohang Branch Extreme Research Plant R&D Department, Korea Institute of Geoscience and Mineral Resources, Pohang 37559, Republic of Korea
E-mail:,
Cell damage, one of critical issues in the bioreactor design for animal cell culture, is caused mainly from the bubble bursting at the free surface subjected to strong extensional flows. In this work, extensive computational studies are performed to investigate bubble bursting process in great details. Extensive numerical simulations are performed for a wide range of bubble diameters (from 0.5 to 6 mm) and the surface tension values (from 0.03 to 0.072 N/m), with which effects of the bubble size and surfactant (PF68) concentration on the hydrodynamic stress are investigated. For all the cases, the maximum extensional stress appears at the instance when receding films impact each other at the bottom of the bubble. A model equation based on numerical simulations is presented to predict the maximum extensional stress as a function of the bubble diameter and the surface tension. The bubble diameter has turned out to contribute significantly the maximum hydrodynamic extensional stress. In addition, the bubble collapsed time and the affected volume around a bubble subjected to the critical extensional stress are investigated. The extensional stress estimation is reported as a function of the bubble size and the surface tension. The influence of the bubble size on the maximum stress dominates and extensional stress reaches up to the order of 104 Pa for bubble size of 0.5 mm.
Keywords:extensional stress;bubble bursting;bioreactor;cell damage;animal cell culture
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