화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.44, 195-203, December, 2016
DOI10.1016/j.jiec.2016.08.032  Export Citation
A synthetic encapsulating emulsifier using complex-forming pentacosadiynoyl cyclosophoraoses (cyclic b-(1, 2)-D-glucan)
Hwanhee Kim, Someshwar D. Dindulkar, Daham Jeong, Seyeon Park1, Bong-Hyun Jun2, Eunae Cho3, and Seunho Jung†
  • Department of Systems Biotechnology, Microbial Carbohydrate Resource Bank (MCRB) & UBITA Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul 143-701, South Korea
  • 1Department of Applied Chemistry, Dongduk Women’s University, Seoul 136-714, South Korea
  • 2Department of Systems Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, South Korea
  • 3Institute for Ubiquitous Information Technology and Applications (UBITA) & Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul 143-701, South Korea
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A new pentacosadiynoyl cyclosophoraose (P-Cys) was synthesized using a biosourced cyclooligosac-charide with intrinsic complexation capacity. NOESY analysis revealed that switchable molecular behavior of pentacosadiynoyl moiety attached to P-Cys was dependent on the external lipophilicity. Both encapsulation by cyclosophoraose and switchable emulsification by pentacosadiynoyl moiety in P-Cys make it possible to finely formulate a nanoemulsion state for an external hydrophobic guest molecule like Sudan III. Various physicochemical properties of the emulsions of P-Cys were investigated using TEM and DLS. The results indicate that P-Cys is a useful potential platform for the encapsulating emulsification of bioactive molecules for cosmetic and pharmaceutical applications.
Keywords:Cyclosophoraoses;Emulsifier;Pentacosadiynyl moiety;NOESY;Nanoemulsion
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