The reactivity of a range of volatile organic compounds with different functional groups observed over 0.5% Pt/γ-Al2O3 catalyst. In general, the reactivity pattern observed was alcohols>aromatics>ketones>carboxylic acids>alkanes. The deep conversion was increased as reaction temperature was increased. A correlation was found between the reactivity of the individual substrates and the strength of the weakest C-H bond in molecular structure. A single weak C-H bond in the substrate led to a high reactivity. The conversion of aromatic solvents increases in order benzene>toluene>ethylbenzene>xylene>styrene. Because the adsorption strength of benzene is stronger than other hydrocarbons, it of volatile organic compounds increases in order methanol>benzene>MEK>n-hexane.