The design and optimization of pressure-swing distillation (PSD) have a critical impact on its economics. An optimization method based on simulated annealing algorithm (SAA) was proposed. The move generator and cooling schedule of the SAA were discussed, and suitable parameter settings were investigated. Two cases of PSD with and without heat integration were optimized by the SAA-based optimization method using procedures of pressure specified and pressure optimized. The results of the process without heat integration were compared with conventional optimization methods. For the acetone-methanol system, the total annual cost (TAC) shows a 5.69% decrease with the pressure specified and a 17.32% decrease with the pressure optimized. For the methanol-chloroform system, the TAC shows a 1.79% decrease with the pressure specified and a 9.04% decrease with the pressure optimized. The SAA-based optimization method has the advantages of a high probability to obtain the global optimum, automatic calculation, and less computing time. (C) 2016 Elsevier Ltd. All rights reserved.