Extraction of lipids from Chlorella algae with supercritical hexane resulted in the high lipids yield of approximately 10% obtained at optimum conditions in terms of extraction time and agitation compared to the total content of lipids being 12%. Furthermore, an easiness of hexane recovery may be considered as economically and ecologically attractive. For the first time, in the current work catalytic hydrodeoxygenation (HDO) of Chlorella algal lipids was studied over 5 wt % Ni/SiO2 at 300 degrees C and under 30 bar total pressure in H-2. The conversion of lipids was about 15% as the catalyst was totally deactivated after 60 min. The transformation of lipids proceeded mostly via hydrogenation and hydrogenolysis with formation of free fatty acid (FFA). Lower activity might be attributed to deactivation of catalysts caused by chlorophylls and carotenoids. Even though the conversion is low, future studies in HDO of lipids extracted from other algae species having higher lipid content could be proposed. A coke resistant catalyst might be considered to improve catalytic activity.