In the present study, the solubility of 4,4'-dihydroxydiphenyl sulfone in mixed solvents of (acetone + methanol), (ethyl acetate + methanol), (acetonitrile + Methanol), and (acetone + methanol) were determined experimentally by using the isothermal dissolution equilibrium method within the temperature range from (278.15 to 313.15) K under atmosphere pressure. The solubility increased with increasing temperature in the binary solvent mixtures at constant solvent composition. At constant temperature and solvent composition, the dissolving capacity of 4,4'-dihydroxydiphenyl sulfone in the four binary solvent mixtures ranked as (acetone + ethanol) > (acetone + methanol) > (ethyl acetate + methanol) > (acetonitrile + methanol). The obtained solubility data were correlated by employing the Jouyban-Acree model, modified Apelblat-Jouyban-Acree model, Ma model and Sun model. The four models were proven to give good representation of the experimental solubility data. The largest value of relative average deviations (RAD) was 4.97 X 10(-2), and that of root-mean-square deviations (RMSD) was 6.49 x 10(-4). The experimental solubility and the models in this study could be helpful in separating 4,4'-dihydroxydiphenyl sulfone from its isomeric mixtures.