The understanding and controlling of biomimetic hybrid materials are a key objective in bio-nanotechnology, materials chemistry, and colloid science fields. Biomaterials, such as, enzyme, DNA, RNA, and proteins have become important templates for the construction of inorganic-organic hybrid nanoflowers. From this perspective, we present a simple approach to synthesize protein and metal hybrid flower-like structure using bovine serum albumin (BSA) and cobalt phosphate, and the results of our study on the formation mechanism involved. The time dependent growing stage and formation mechanism were analyzed by electron microscopes and spectroscopic techniques. The protein-directed assembly method for preparation of hybrid nanoflowers described in this work could be used to fabricate other bio-metal hybrid materials with possible applications in biosensors, bioanalytical devices, and industrial biocatalyst fields. (C) 2016 Elsevier Inc. All rights reserved.