Transmission infrared spectroscopy is employed to study the oxidation of C3F6 on TiO2 particles. TiO2, alone, without dispersion of any transition metals, is capable of oxidizing C3F6 to completion in O-2(g) at similar to 600 K. CO2 and CO were found to be the two major products. The initial stage of the C3F6 oxidation on TiO2 follows the conventional redox mechanism : the Mars-van Krevelen cycle which involves both lattice and gaseous oxygen. CF3COO(a) was found to be a reaction intermediate on the TiO2 surface. Water was observed to reduce the oxidation rate of C3F6. A mechanism involving surface CF3COO(a) and FCOO(a) is proposed. Consumption of Ti occurs, producing TiF4(g) during the oxidation reaction.