Skin permeability of compounds loaded within dissolving microneedles dependent on composition of sodium hyaluronate and carboxymethyl cellulose

Youbin Park; Bumsang Kim

Korean Journal of Chemical Engineering, Vol.34, No.1, 133-138, January, 2017

DOI10.1007/s11814-016-0240-1 Export Citation

Skin permeability of compounds loaded within dissolving microneedles dependent on composition of sodium hyaluronate and carboxymethyl cellulose

Youbin Park, and Bumsang Kim^†

Department of Chemical Engineering, Hongik University, Seoul 04066, Korea

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Dissolving microneedles are transdermal delivery systems designed to mechanically penetrate the skin and fully dissolve in the skin in a minimally invasive manner. In this study, the skin permeability of compounds encapsulated in microneedles was controlled by changing the composition of microneedle materials. Sodium hyaluronate (SH) and carboxymethyl cellulose (CMC) were chosen as structural materials and amylopectin was used to increase the mechanical strength of microneedles. To determine the effect of microneedle composition on skin permeability, microneedle properties such as mechanical strength and solubility were investigated according to various compositions of SH and CMC. When the CMC fraction in the needle increased, the mechanical strength of the microneedle increased, leading to high skin permeability of rhodamine B, a model compound. Using microneedles, significantly higher skin permeability of niacinamide was also obtained. These results indicate that the microneedles developed in this study improved the skin permeability of compounds loaded in the needle, and the skin permeability could be tuned by changing the composition of microneedle materials.

Keywords:Dissolving Microneedles;Microneedle Composition;Skin Permeability;Sodium Hyaluronate;Carboxymethyl Cellulose

[References]

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Sunkavalli S, Eedara BB, Janga KY, Velpula A, Jukanti R, Bandari S, Korean J. Chem. Eng., 33(3), 1115 (2016)
Kim YC, Park JH, Prausnitz MR, Adv. Drug Deliv. Rev., 64, 1547 (2012)
Prausnitz MR, Adv. Drug Deliv. Rev., 56, 581 (2004)
Van der Maaden K, Jiskoot W, Bouwstra J, J. Control. Release, 161, 645 (2012)
Lee JW, Park JH, Prausnitz MR, J. Biomater., 29, 2113 (2008)
Liu S, Jin MN, Quan YS, Kamiyama F, Kusamori K, Katsumi H, Yamamoto A, Eur. J. Pharm., 86, 267 (2014)
Kim JD, Kim M, Yang H, Lee K, Jung H, J. Control. Release, 170, 430 (2013)
Zhu Z, Luo H, Lu W, Laun H, Wu Y, Luo J, Wang Y, Pi J, Lim CY, Wang H, Pharm Res., 31, 3348 (2014)
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Korkmaz E, Friedrich EE, Ramadan MH, Erdos G, Mathers AR, Ozdoganlar OB, Washburn NR, Falo LD, Acta. Biomater., 24, 96 (2015)
Park YH, Sang KH, Choi IW, Kim KS, Park JY, Choi NW, Kim B, Sung JH, Biotech. Bioproc. Eng., 21, 110 (2016)
Lee SH, Lee HH, Choi SS, Korean J. Chem. Eng., 28(9), 1913 (2011)
Jung SM, Kim HJ, Kim BJ, Joo GS, Yoon TS, Kim YS, Lee HH, BioChip. J., 3, 219 (2009)
Park JH, Allen MG, Prausnitz MR, J. Control. Release, 104, 51 (2005)
Feng XH, Pelton R, Leduc M, Ind. Eng. Chem. Res., 45(20), 6665 (2006)
Hong X, Wu Z, Chen L, Wu F, Wei L, Yuan W, Nano-Micro. Lett., 6, 191 (2014)
Soma Y, Kashima M, Imaizumi A, Takahama H, Kawakami T, Mizoquchi M, Int. J. Dermatol., 44, 197 (2005)
Wohlrab J, Kreft D, Skin. Pharmacol. Phys., 27, 311 (2014)

[Referenced By]

[1] Giudice EL, Campbell JD, Adv. Drug Deliv. Rev., 58, 68 (2006)

[2] Ito Y, Yoshimura M, Tanaka T, Takada K, J. Pharm. Sci., 101, 1145 (2012)

[3] Sunkavalli S, Eedara BB, Janga KY, Velpula A, Jukanti R, Bandari S, Korean J. Chem. Eng., 33(3), 1115 (2016)

[4] Kim YC, Park JH, Prausnitz MR, Adv. Drug Deliv. Rev., 64, 1547 (2012)

[5] Prausnitz MR, Adv. Drug Deliv. Rev., 56, 581 (2004)

[6] Van der Maaden K, Jiskoot W, Bouwstra J, J. Control. Release, 161, 645 (2012)

[7] Lee JW, Park JH, Prausnitz MR, J. Biomater., 29, 2113 (2008)

[8] Liu S, Jin MN, Quan YS, Kamiyama F, Kusamori K, Katsumi H, Yamamoto A, Eur. J. Pharm., 86, 267 (2014)

[9] Kim JD, Kim M, Yang H, Lee K, Jung H, J. Control. Release, 170, 430 (2013)

[10] Zhu Z, Luo H, Lu W, Laun H, Wu Y, Luo J, Wang Y, Pi J, Lim CY, Wang H, Pharm Res., 31, 3348 (2014)

[11] Monkare J, Nejadnik MR, Baccouche K, Romeijn S, Jiskoot W, Bouwstra JA, J. Control. Release, 218, 53 (2015)

[12] Korkmaz E, Friedrich EE, Ramadan MH, Erdos G, Mathers AR, Ozdoganlar OB, Washburn NR, Falo LD, Acta. Biomater., 24, 96 (2015)

[13] Park YH, Sang KH, Choi IW, Kim KS, Park JY, Choi NW, Kim B, Sung JH, Biotech. Bioproc. Eng., 21, 110 (2016)

[14] Lee SH, Lee HH, Choi SS, Korean J. Chem. Eng., 28(9), 1913 (2011)

[15] Jung SM, Kim HJ, Kim BJ, Joo GS, Yoon TS, Kim YS, Lee HH, BioChip. J., 3, 219 (2009)

[16] Park JH, Allen MG, Prausnitz MR, J. Control. Release, 104, 51 (2005)

[17] Feng XH, Pelton R, Leduc M, Ind. Eng. Chem. Res., 45(20), 6665 (2006)

[18] Hong X, Wu Z, Chen L, Wu F, Wei L, Yuan W, Nano-Micro. Lett., 6, 191 (2014)

[19] Soma Y, Kashima M, Imaizumi A, Takahama H, Kawakami T, Mizoquchi M, Int. J. Dermatol., 44, 197 (2005)

[20] Wohlrab J, Kreft D, Skin. Pharmacol. Phys., 27, 311 (2014)