A miniature device for shock initiation of the hexanitrostilbene (HNS) through micro-charge detonation-driven flyer was fabricated. This device consisted of the substrate, micro-charge, flyer, and barrel. Four types of flyer (titanium of 28m, aluminum of 22m, copper of 22m and polyimide (PI) of 55m in thickness) were studied and the effect of micro-charge thickness, diameter, and barrel length were investigated by measuring the average flyer velocities using polyvinylidene fluoride (PVDF) films. The results show that the titanium flyer is more proper for such initiation device compared to aluminum, copper, and polyimide flyer. The average velocity of the flyer increased with the thickness of micro-charge and the increment was larger when the thickness increases from 0.3mm to 0.4mm than when the thickness increases from 0.4mm to 0.6mm. The flyer velocity significantly increased with the increase in the diameter of micro-charge until a plateau appeared at 0.8mm. The flyer velocity increased first and then decreased sharply with the increase in barrel length. The average velocity for a 28m thick titanium flyer was measured to be as high as 2468ms(-1) when the thickness, micro-charge diameter and the length of barrel were 0.6mm, 0.8mm and 659m, respectively. The HNS-IV explosive with density 1.57gcm(-3) was initiated by this miniature device.