Level of Mg and Ca was detd. in bones of the cranial vault in 8-month-old rats whose mothers received 5 mu g/kg b.w. of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) three weeks before insemination. A simultaneous treatment with a-tocopherol (vitamin E) in the 30 mg/kg b.w. (TCDD + E group vitamin) or 420 mg/kg b.w. (TCDD + E group vitamin) dose was carried out for 3 weeks. The control group consisted of subjects whose mothers did not receive any pharmacol. treatment. Statistically significant differences in ay. Mg and Ca concns. were obsd. A protective effect of a low dose of a-tocopherol on Mg and Ca level in the bone tissue of rat offspring after intoxicating rat females with TCDD before insemination was evidenced.